Customize Consent Preferences

We use cookies to help you navigate efficiently and perform certain functions. You will find detailed information about all cookies under each consent category below.

The cookies that are categorized as "Necessary" are stored on your browser as they are essential for enabling the basic functionalities of the site. ... 

Always Active

Necessary cookies are required to enable the basic features of this site, such as providing secure log-in or adjusting your consent preferences. These cookies do not store any personally identifiable data.

No cookies to display.

Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms, collecting feedback, and other third-party features.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics such as the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Advertisement cookies are used to provide visitors with customized advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns.

No cookies to display.

Hi friends!

 

Today is a beautiful day in Stockholm with blue sky. However, I had a headache yesterday which unfortunately has continued today. Measured my blood pressure which is to high, both of them. Two months ago I started to wear lenses, maybe that is the problem. I will go back to wear glasses. So I have to stay at home and rest in peace. Talked to my parents  and they are making cinnamon rolls today. Lady and Tippa are both fine. If I get better I will make some apple (from the countryside) muffins later. So today is a lazy day. Hope I get better so I can go to work tomorrow.

Almost a year has passed since I wrote my very first poem and that was at halloween 2012. This website is supposed to give me energy. I actually re-read what I have written some times. My diary.

Have nice day!

Anna

///////////////////////////////////////////////////////////////////////////////

Since I am not directly involved in science I will instead present theoretical science. This is not something that is finished this year. I will make some small changes and because I don´t have access to anything but my memory I will build research from my memory. Grammar etcetera may not be right.

This is very difficult, I can assure, but challenging.

——————————————-

“Je pense, donc je suis”

Descartes

——————————————–

I have thought for quite same time; and these are my working hypotheses:

1) Dopamine and -acetylcholine hypothesis

Smoking (or other forms of nicotine intake) is very common in several diseases. Professor Arvid Carlsson (Göteborgs Universitet, Sweden) has hypothesised in the 1950’s that dopamine is involved in the pathophysiology of eg addiction (Engel and Söderpalm 1999; Yoshida et al 1980), schizophrenia and Parkinson´s disease. (don´t know about Alzheimers disease). Smoking is highly observed among alcohol dependent individuals, depression, schizophrenia.

Several experiments in vivo have demonstrated that dopamine plays a crucial role in these diseases. Professor Arvid Carlsson has further gained evidence for the hypothesis by introducing dopamine stabilisers. A pharmacological substance, with dual effects, acting as an agonist and antagonist depending on the state of the environment. (Since I write this from my memory, it may not be accurate).

However, as seen in Parkinson´s disease, today´s available pharmacological treatment is not optimal. On-off symptoms may be observed.

Dopamine neurons are widely distributed throughout the brain in rather distinct pathways. These neurons are closely located to eg cholinergic neurons. Cholinergic neurons have muscarinic (G-protein coupled) and nicotinic receptors (ion channels). To the best of my knowledge, dopamine neurons do not have ionic receptors. Maybe they are equipped with rapidly responding receptors, but they have not been found or simply: they do not exist. I don´t know the literature.

Inte helt lätt att hålla röda tråden…Men det är ett andra utkast.

A possible way to reduce side-effects may be to give more input to dopaminergic activity by cholinergic sparkling eg from the mesopontine area.

Since I have experienced that data can be stolen I publish this in public so everybody can get the information. It might be wrong but that is what a hypothesis may be. Probably it is right but it may also be wrong. Or something in-between. Only experiments can find out to get evidence for the hypothesis to help individuals with proper treatment.

Hopefully I can help people. Maybe somebody will read this and get ethical approval.

 

2) Prevention of diseases in humans later in life is to monitor ophthalmological status in newborns – to obtain stability in the body

Since I have read a lot about the brain in the literature a decade ago I have had time to reflect. It is interesting to note that the

I believe (a hypothesis that might be wrong) that the development of the ophthalmological nervous system is very important for the brain, our function to be. Both “eyes” need to be in balance during development. However, since the brain is adaptable to changes, can later be corrected, and balance can be re-obtained.

These are just, so far some ideas, so they are not true.

3) Is it possible to predict depression by monitoring cortisol levels, and can beta-blockers (not crossing the blood-brain barrier, “heart-selective”, eg metoprolol) together with SSRI (sertralin) contribute to a rapid recovery and hampering of ?

Jag undrar om depression kan på något sätt försämra hjärnans funktion, alltså, utan depression är hjärnan ok, men en hjärna som varit med om en depression kan sensitiseras och därmed vara känsligare i framtiden. Det skulle eventuellt, den mycket välkända beta-blockeraren metoprolol hjälpa till att lindra. En låg dos kanske 25 mg dagligen.

Om så är fallet, skulle det med en redan väl beprövad beta-blockerare kunna

These questions need to be further explained, I have not fully formulated good questions and thoughts.

 

Leave a Reply

Your email address will not be published. Required fields are marked *